Modeling disease at the intersection of math, biology, and medicine.
Dr. Mochel leads translational research at UGA's College of Veterinary Medicine, combining 3D organoid platforms with mathematical pharmacology to build better models of disease and drug response — for dogs, and for humans.
The Mochel lab bridges pharmacokinetics, mathematical modeling, and 3D organoid biology to build clinically relevant preclinical models — using dogs as sentinels for human disease.
Integrating pharmacokinetic and pharmacodynamic principles with computational dose-response frameworks. The lab builds and validates in vitro–in silico platforms that predict drug behavior at tissue, organ, and whole-animal scale — enabling rational dosing for veterinary and human drugs.
Building and characterizing adult stem cell-derived organoids from 12+ canine tissue types — intestine, bladder, liver, lung, and more. These 3D mini-organs enable high-content drug screening, disease modeling, and toxicology studies without live animals.
Dogs develop many of the same cancers, GI diseases, and metabolic conditions as humans — spontaneously, and with similar genetics. The Mochel lab leverages this natural overlap to validate canine patient-derived organoids as clinically relevant surrogates for human preclinical models.
Applying systems biology frameworks to cancer research — including canine urothelial carcinoma, GI tumors, and avian influenza models. Recent work includes OrganoidChip+ microfluidic platforms and bioengineered gut bacteria as Parkinson's disease therapeutics.
Peer-reviewed research spanning organoid pharmacology, PK/PD modeling, and veterinary internal medicine.
Dr. Mochel works across veterinary and human medicine, partnering with bioengineers, oncologists, neurologists, and pharmacologists at institutions worldwide.
Dr. Mochel welcomes inquiries from industry partners, academic collaborators, graduate students, and postdoctoral fellows interested in organoid-based pharmacology and veterinary translational medicine.
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